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Talha Munir, MD | szakcikk |

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3054 Using Ibrutinib in Earlier Lines of Treatment Results in Better Outcomes for Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Szerző: Paul M. Barr, MD1 Alessandra Tedeschi, MD2 Talha Munir, MD3 Peter Hillmen, MD, PhD4 John C Byrd, MD5 Paolo Ghia, MD, PhD6 Stephen Mulligan, MBBS, MD, FRACP, FRCPA7 Sandra Dai, PhD, MS8 Carlos Amaya-Chanaga, MD9 James P. Dean, MD, PhD10 Susan M. o'Brien, MD11
1Division of Hematology/Oncology, Wilmot Cancer Institute, University of Rochester, Rochester, NY
2Department of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
3Department of Haematology, Leeds Teaching Hospitals, Leeds, United Kingdom
4The Leeds Teaching Hospitals, St. James University Hospital, (Leeds Cancer Centre, St. James' Institute of Oncology), Leeds, United Kingdom
5The Ohio State University, Columbus, OH; Comprehensive Cancer Center, The Ohio State University, Columbus, OH
6Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy
7Royal North Shore Hospital, Sydney, AUS
8Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA
9Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA
10Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA
11UC Irvine, Chao Family Comprehensive Cancer Center, Orange, CA

Background: Ibrutinib is the only once-daily Bruton’s tyrosine kinase inhibitor with significant progression-free survival (PFS) benefit demonstrated in 5 randomized phase 3 studies in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) compared with standard-of-care chemotherapy and/or immunotherapy (RESONATE, RESONATE-2, iLLUMINATE, Alliance 041202, and ECOG 1912), and significant overall survival (OS) benefit in 3...


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